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Senior Research Fellow

Dr Chantelle Ahlenstiel

  • Bachelor of Advanced Science (Hons 1st class), USyd in 2000.
  • PhD in Infectious Diseases, USyd in 2004.
  • Postdoctoral fellowship at Vaccine Reserach Center, NIH from 2004-2009.
  • Reserach Fellow in Immunovirology & Pathogenesis Program (IVPP) at the Kirby Institute, UNSW from 2009-current.
9385 0198

NHMRC Project Grant APP1128012.

Investigates the components and mechanisms involved in RNA-directed transcriptional gene silencing, specifically short interfering RNA (siRNA) and short hairpin RNA (shRNA), to control SIV & HIV-1 virus replication.

Current projects in the lab involve;

- Live cell imaging techniques to capture in real time siRNA being trafficked into the nucleus of cells infected with HIV-1.

- Live cell imaging techniques to define the role of F-actin during transcriptioal gene silencing of HIV-1.

-Characterisation of transcriptional gene silencing in HIV-1 infected cells of CNS origin.

-In vivo experiments using a humanised mouse model of HIV-1 to confirm the protective effect of specific shRNA targeting HIV-1.

-Investigating the use of nanoparticles to deliver si/shRNA targeting HIV-1 in various cell types relevant to the HIV-1 latent reservoir.

Honours, Masters and PhD students.

HIV-1, gene therapy approaches