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Dr Gabriel Duette – HIV persistence is promoted by the TB-Associated Microenvironment

Event date
Tuesday 7 November
Event time
1:00pm - 2:00pm
Event address
In-person & online. Kirby Institute, Seminar Room Level 6, Wallace Wurth Building, Kensington Campus, UNSW Sydney

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the main cause of death in HIV-1-infected people. Our study explores the impact of the Mtb-induced inflammatory microenvironment on HIV-1 persistence. We found impaired HIV-1-specific CD8 T-cell response, leading to higher infected cell proportions at the coinfection site.

Dr Gabriel Duette

Dr Gabriel Duette
Postdoctoral Researcher at the Centre for Virus Research, The Westmead Institute for Medical Research

In 2019, Dr Duette obtained his PhD from the University of Buenos Aires, focusing on HIV immunopathology and Extracellular Vesicles. Since September 2019, as a Postdoctoral researcher at The Westmead Institute for Medical Research, he has studied HIV persistence in effector memory T cells and the impact of type 1 IFN on HIV reactivation. Additionally, he contributed to COVID research.

Currently, Dr Duette investigates HIV/TB coinfection's effect on the HIV reservoir and works on generating CD8 CAR T cells for HIV eradication. Moreover, he aims to understand transient HIV control during an analytical treatment interruption (ATI).

Opinions expressed by individuals at this event are solely of those of the individual/s and do not necessarily represent the views or opinions of the Kirby Institute or UNSW.