John Zaunders is a Senior Scientist at St Vincent’s Hospital, Sydney, whose research encompasses the immunology of HIV and other infectious diseases, based on expertise in flow cytometry and immunological techniques. He has contributed pioneering work in human CD4 T cell subsets, including immunophenotyping of Tregs; study of CCR5+ CD4 T cells, especially activated CCR5+ viral antigen-specific CD4 T cells during acute infection and after vaccination; cytotoxic CD4 T lymphocytes in human viral infections; and the role of T follicular helper cells in human lymph nodes and gut associated lymphoid tissue, during chronic HIV infection, as well as after vaccination. Most recently, he has been involved in dissecting CD4 T cell responses to SARS-CoV-2 infection and to vaccination.
Selected recent publications
H. Law, … J. Zaunders, A. D. Kelleher, C. M. L. Munier, Early expansion of CD38+ICOS+ GC Tfh in draining lymph nodes during influenza vaccination immune response. iScience 25, 103656 (2022).
J. Massey, K. Jackson, M. Singh, … J. Zaunders, … J. Moore, I. Sutton, Haematopoietic Stem Cell Transplantation Results in Extensive Remodelling of the Clonal T Cell Repertoire in Multiple Sclerosis. Front Immunol 13, 798300 (2022).
C. Petitdemange, N. Funderburg, J. Zaunders, P. Corbeau, Infectious Agent-Induced Chronic Immune Activation: Causes, Phenotypes, and Consequences. Front Immunol 12, 740556 (2021).
Suzuki, K., … and Zaunders, J. HIV-1 viral blips are associated with repeated and increasingly high levels of cell-associated HIV-1 RNA transcriptional activity. AIDS, 2021, 35, 2095-2103.
J Zaunders and C Phetsouphanh. Long term and short-term immunity to SARS-CoV-2 – why it matters. 2021 Microbiology Australia, published online 13th April, 2021.
Mak, G., Zaunders, J et al., Preservation of Gastrointestinal Mucosal Barrier Function and Microbiome in Patients With Controlled HIV Infection. Front Immunol, 2021. 12: p. 688886.
K. Frith, C. M. L. Munier, … and J. J. Zaunders, The Role of ZEB2 in Human CD8 T Lymphocytes: Clinical and Cellular Immune Profiling in Mowat-Wilson Syndrome. International journal of molecular sciences 22, (2021).
Zaunders, J., et al., Mapping the extent of heterogeneity of human CCR5+ CD4+ T cells in peripheral blood and lymph nodes. AIDS, 2020. 34(6): p. 833-848.
Hey-Nguyen, W.J., … Zaunders, J, and Koelsch, K. Quantification of Residual Germinal Center Activity and HIV-1 DNA and RNA Levels Using Fine Needle Biopsies of Lymph Nodes During Antiretroviral Therapy. AIDS Res Hum Retroviruses, 2017. 33(7): p. 648-657.