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Adjunct Professor

Professor Kate Louise Seib

E-mail
k.seib@griffith.edu.au
Location
Institute for Biomedicine and Glycomics, Griffith University, Gold Coast,QLD
Ascari A; Taha ; Davis RA; Seib KL; Semchenko EA, 2026, 'Antimicrobial activity of natural quinone-methide triterpenoids celastrol and pristimerin against pathogenic Neisseria', Microbiology Spectrum, 14, pp. 1 - 12, http://dx.doi.org/10.1128/spectrum.02724-25
2026
Williams E; Low SJ; Pollock GL; Taouk ML; Prestedge J; Howden BP; Chow EPF; Fairley CK; Seib KL; McCarthy JS; Pasricha S; Williamson DA, 2025, 'Selecting candidate Neisseria gonorrhoeae strains for oropharyngeal gonorrhoea human challenge: a genomics-based analysis of clinical isolates', Lancet Microbe, 6, http://dx.doi.org/10.1016/j.lanmic.2025.101105
2025
Ong JJ; Unemo M; Molina JM; Miranda AE; Seib KL; Brito de Mello M; Doherty M; Johnson CC; Delany-Moretlwe S; Fairley C, 2025, 'Beyond behavioural change: prioritising structural solutions to control bacterial sexually transmitted infections', Eclinicalmedicine, 83, http://dx.doi.org/10.1016/j.eclinm.2025.103198
2025
Ryan FJ; Clarke M; Lynn MA; Benson SC; McAlister S; Giles LC; Choo JM; Rossouw C; Ng YY; Semchenko EA; Richard A; Leong LEX; Taylor SL; Blake SJ; Mugabushaka JI; Walker M; Wesselingh SL; Licciardi PV; Seib KL; Tumes DJ; Richmond P; Rogers GB; Marshall HS; Lynn DJ, 2025, 'Bifidobacteria support optimal infant vaccine responses', Nature, 641, pp. 456 - 464, http://dx.doi.org/10.1038/s41586-025-08796-4
2025
Ngoo A; Semchenko EA; Atack A; Thomas PB; Seib KL; Vela I; Williams ED, 2025, 'Could Neisseria gonorrhoeae have carcinogenic potential? A critical review of current evidence', Critical Reviews in Microbiology, 51, pp. 954 - 965, http://dx.doi.org/10.1080/1040841X.2024.2448166
2025
Williams E; Pollock GL; Price DJ; Crocker-Buque T; de Kretser D; Jamrozik E; Osowicki J; Pasricha S; Azzato F; Steer A; Groom JR; Hill DL; Roberts JA; Huston WM; Seib KL; Fairley CK; Chow EPF; Chen MY; Hocking JS; Williamson DA; McCarthy JS, 2025, 'An oropharyngeal gonorrhoea controlled human infection model: a provisional protocol using a novel Neisseria gonorrhoeae challenge strain', Wellcome Open Research, 10, http://dx.doi.org/10.12688/wellcomeopenres.25103.1
2025
Seib KL; Donovan B; Thng C; Lewis DA; McNulty A; Fairley CK; Yeung B; Jin F; Fraser D; Bavinton BR; Law M; Chen MY; Chow EPF; Whiley DM; Mackie B; Jennings MP; Jennison AV; Lahra MM; Grulich AE, 2024, 'Multicentre double-blind randomised placebo-controlled trial evaluating the efficacy of the meningococcal B vaccine, 4CMenB (Bexsero), against Neisseria gonorrhoeae infection in men who have sex with men: the GoGoVax study protocol', BMJ Open, 14, http://dx.doi.org/10.1136/bmjopen-2023-081675
2024
Padeniya TN; Hui BB; Wood JG; Regan DG; Seib KL, 2024, 'Review of mathematical models of Neisseria gonorrhoeae vaccine impact: Implications for vaccine development', Vaccine, 42, pp. S70 - S81, http://dx.doi.org/10.1016/j.vaccine.2024.03.068
2024
Gottlieb SL; Spielman E; Abu-Raddad L; Aderoba AK; Bachmann LH; Blondeel K; Chen XS; Crucitti T; Camacho GG; Godbole S; de Leon RGP; Gupta S; Hermez J; Ishikawa N; Klausner JD; Kurbonov F; Maatouk I; Mandil A; Mello MB; Miranda AE; Mosha FS; Okeibunor JC; Ong JJ; Peters RPH; Pérez F; Seguy N; Seib KL; Sharma M; Sladden T; Van Der Pol B; White PJ; Wi T; Broutet N, 2024, 'WHO global research priorities for sexually transmitted infections', Lancet Global Health, 12, pp. e1544 - e1551, http://dx.doi.org/10.1016/S2214-109X(24)00266-3
2024
Williams E; Seib KL; Fairley CK; Pollock GL; Hocking JS; McCarthy JS; Williamson DA, 2024, 'Neisseria gonorrhoeae vaccines: a contemporary overview', Clinical Microbiology Reviews, 37, http://dx.doi.org/10.1128/cmr.00094-23
2024
Lyu Y; Choong A; Chow EPF; Seib KL; Marshall HS; Unemo M; de Voux A; Wang B; Miranda AE; Gottlieb SL; Mello MB; Wi T; Baggaley R; Marshall C; Abu-Raddad LJ; Abara WE; Chen XS; Ong JJ, 2024, 'Vaccine value profile for Neisseria gonorrhoeae', Vaccine, 42, pp. S42 - S69, http://dx.doi.org/10.1016/j.vaccine.2023.01.053
2024
Chow EPF; Stevens K; De Petra V; Chen MY; Bradshaw CS; Sherry NL; Barbee LA; Vodstrcil LA; Aguirre I; Seib KL; Maddaford K; Williamson DA; Howden BP; Fairley CK, 2024, 'Prevalence of Cefixime-Resistant Neisseria gonorrhoeae in Melbourne, Australia, 2021-2022', Journal of Infectious Diseases, 230, pp. e1121 - e1125, http://dx.doi.org/10.1093/infdis/jiae313
2024
Taha ; Eskandari S; Slesarenko VA; Haselhorst T; Semchenko EA; Seib KL, 2024, 'Refinement and optimisation of Neisseria gonorrhoeae NHBA and MetQ vaccine candidates', Vaccine, 42, http://dx.doi.org/10.1016/j.vaccine.2024.126416
2024
Wang B; Seib KL; Marshall H, 2024, 'The future role of vaccination in prevention of Neisseria gonorrhoeae', Microbiology Australia, 45, pp. 117 - 121, http://dx.doi.org/10.1071/MA24034
2024
Padeniya TN; Hui BB; Wood JG; Seib KL; Regan DG, 2023, 'The potential impact of a vaccine on Neisseria gonorrhoeae prevalence among heterosexuals living in a high prevalence setting', Vaccine, 41, pp. 5553 - 5561, http://dx.doi.org/10.1016/j.vaccine.2023.07.048
2023
Thng C; Semchenko EA; Hughes I; O’Sullivan M; Seib KL, 2023, 'An open-label randomised controlled trial evaluating the efficacy of a meningococcal serogroup B (4CMenB) vaccine on Neisseria gonorrhoeae infection in gay and bisexual men: the MenGO study protocol', BMC Public Health, 23, http://dx.doi.org/10.1186/s12889-023-15516-y
2023
Branch AH; Stoudenmire JL; Seib KL; Cornelissen CN, 2022, 'Acclimation to Nutritional Immunity and Metal Intoxication Requires Zinc, Manganese, and Copper Homeostasis in the Pathogenic Neisseriae', Frontiers in Cellular and Infection Microbiology, 12, http://dx.doi.org/10.3389/fcimb.2022.909888
2022
Semchenko EA; Seib KL, 2022, 'Outer membrane vesicle vaccines for Neisseria gonorrhoeae', Nature Reviews Urology, 19, pp. 5 - 6, http://dx.doi.org/10.1038/s41585-021-00534-5
2022
Evert BJ; Slesarenko VA; Punnasseril JMJ; Taha ; Zhan J; Zhou Y; Semchenko EA; Seib KL, 2022, 'Self-Inhibitory Peptides Targeting the Neisseria gonorrhoeae MtrCDE Efflux Pump Increase Antibiotic Susceptibility', Antimicrobial Agents and Chemotherapy, 66, http://dx.doi.org/10.1128/AAC.01542-21
2022
Hui BB; Padeniya TN; Rebuli N; Gray RT; Wood JG; Donovan B; Duan Q; Guy R; Hocking JS; Lahra MM; Lewis DA; Whiley DM; Regan DG; Seib KL, 2022, 'A Gonococcal Vaccine Has the Potential to Rapidly Reduce the Incidence of Neisseria gonorrhoeae Infection among Urban Men Who Have Sex with Men', Journal of Infectious Diseases, 225, pp. 983 - 993, http://dx.doi.org/10.1093/infdis/jiab581
2022
Jen FEC; Ketterer MR; Semchenko EA; Day CJ; Jennings MP; Seib KL; Apicella MA, 2021, 'The lst sialyltransferase of neisseria gonorrhoeae can transfer keto-deoxyoctanoate as the terminal sugar of lipooligosaccharide: A glyco-achilles heel that provides a new strategy for vaccines to prevent gonorrhea', Mbio, 12, http://dx.doi.org/10.1128/mBio.03666-20
2021
Ruiz García Y; Sohn WY; Seib KL; Taha MK; Vázquez JA; de Lemos APS; Vadivelu K; Pizza M; Rappuoli R; Bekkat-Berkani R, 2021, 'Looking beyond meningococcal B with the 4CMenB vaccine: the Neisseria effect', Npj Vaccines, 6, http://dx.doi.org/10.1038/s41541-021-00388-3
2021
Gottlieb SL; Ndowa F; Hook EW; Deal C; Bachmann L; Abu-Raddad L; Chen XS; Jerse A; Low N; MacLennan CA; Petousis-Harris H; Seib KL; Unemo M; Vincent L; Giersing BK, 2020, 'Gonococcal vaccines: Public health value and preferred product characteristics; report of a WHO global stakeholder consultation, January 2019', Vaccine, 38, pp. 4362 - 4373, http://dx.doi.org/10.1016/j.vaccine.2020.02.073
2020
Semchenko EA; Mubaiwa TD; Day CJ; Seib KL, 2020, 'Role of the Gonococcal Neisserial Heparin Binding Antigen in Microcolony Formation, and Serum Resistance and Adherence to Epithelial Cells', Journal of Infectious Diseases, 221, pp. 1612 - 1622, http://dx.doi.org/10.1093/infdis/jiz628
2020
Semchenko EA; Day CJ; Seib KL, 2020, 'The neisseria gonorrhoeae vaccine candidate nhba elicits antibodies that are bactericidal, opsonophagocytic and that reduce gonococcal adherence to epithelial cells', Vaccines, 8, http://dx.doi.org/10.3390/vaccines8020219
2020
Seib KL; Srikhanta YN; Atack JM; Jennings MP, 2020, 'Epigenetic Regulation of Virulence and Immunoevasion by Phase-Variable Restriction-Modification Systems in Bacterial Pathogens', Annual Review of Microbiology, 74, pp. 655 - 671, http://dx.doi.org/10.1146/annurev-micro-090817-062346
2020
Jen FEC; Scott AL; Tan A; Seib KL; Jennings MP, 2020, 'Random Switching of the ModA11 Type III DNA Methyltransferase of Neisseria meningitidis Regulates Entner–Doudoroff Aldolase Expression by a Methylation Change in the eda Promoter Region', Journal of Molecular Biology, 432, pp. 5835 - 5842, http://dx.doi.org/10.1016/j.jmb.2020.08.024
2020
Tan A; Blakeway LV; Taha ; Yang Y; Zhou Y; Atack JM; Peak IR; Seib KL, 2020, 'Moraxella catarrhalis phase-variable loci show differences in expression during conditions relevant to disease', Plos One, 15, http://dx.doi.org/10.1371/journal.pone.0234306
2020
Blakeway LV; Tan A; Peak IR; Atack JM; Seib KL, 2020, 'Proteome of a Moraxella catarrhalis Strain under Iron-Restricted Conditions', Microbiology Resource Announcements, 9, http://dx.doi.org/10.1128/MRA.00064-20
2020
Blakeway LV; Tan A; Peak IR; Atack JM; Seib KL, 2020, 'Transcriptome RNA sequencing data set of gene expression in moraxella catarrhalis on- And off-phase variants of the type III DNA methyltransferase ModM3', Microbiology Resource Announcements, 9, http://dx.doi.org/10.1128/MRA.01559-19
2020
Semchenko EA; Chen X; Thng C; O'Sullivan M; Seib KL, 2020, 'Gonorrhoea: Past, present and future', Microbiology Australia, 41, pp. 205 - 209, http://dx.doi.org/10.1071/ma20055
2020
Zhan J; Jia H; Semchenko EA; Bian Y; Zhou AM; Li Z; Yang Y; Wang J; Sarkar S; Totsika M; Blanchard H; Jen FEC; Ye Q; Haselhorst T; Jennings MP; Seib KL; Zhou Y, 2019, 'Self-derived structure-disrupting peptides targeting methionine aminopeptidase in pathogenic bacteria: A new strategy to generate antimicrobial peptides', FASEB Journal, 33, pp. 2095 - 2104, http://dx.doi.org/10.1096/fj.201700613RR
2019
Hartley-Tassell LE; Awad MM; Seib KL; Scarselli M; Savino S; Tiralongo J; Lyras D; Day CJ; Jennings MP, 2019, 'Lectin activity of the TcdA and TcdB toxins of Clostridium difficile', Infection and Immunity, 87, http://dx.doi.org/10.1128/IAI.00676-18
2019
Palmu AA; Ware RS; Lambert SB; Sarna M; Bialasiewicz S; Seib KL; Atack JM; Nissen MD; Grimwood K, 2019, 'Nasal swab bacteriology by PCR during the first 24-months of life: A prospective birth cohort study', Pediatric Pulmonology, 54, pp. 289 - 296, http://dx.doi.org/10.1002/ppul.24231
2019
Phillips ZN; Brizuela C; Jennison AV; Staples M; Grimwood K; Seib KL; Jennings MP; Atack JM, 2019, 'Analysis of invasive nontypeable Haemophilus influenzae isolates reveals selection for the expression state of particular phase-variable lipooligosaccharide biosynthetic genes', Infection and Immunity, 87, http://dx.doi.org/10.1128/IAI.00093-19
2019
Brown P; Zhou Y; Tan AC; El-Esawi MA; Liehr T; Blanck O; Gladue DP; Almeida GMF; Cernava T; Sorzano CO; Yeung AWK; Engel MS; Chandrasekaran AR; Muth T; Staege MS; Daulatabad SV; Widera D; Zhang J; Meule A; Honjo K; Pourret O; Yin CC; Zhang Z; Cascella M; Flegel WA; Goodyear CS; van Raaij MJ; Bukowy-Bieryllo Z; Campana LG; Kurniawan NA; Lalaouna D; Hüttner FJ; Ammerman BA; Ehret F; Cobine PA; Tan EC; Han H; Xia W; McCrum C; Dings RPM; Marinello F; Nilsson H; Nixon B; Voskarides K; Yang L; Costa VD; Bengtsson-Palme J; Bradshaw W; Grimm DG; Kumar N; Martis E; Prieto D; Sabnis SC; Amer SEDR; Liew AWC; Perco P; Rahimi F; Riva G; Zhang C; Devkota HP; Ogami K; Basharat Z; Fierz W; Siebers R; Tan KH; Boehme KA; Brenneisen P; Brown JAL; Dalrymple BP; Harvey DJ; Ng G; Werten S; Bleackley M; Dai Z; Dhariwal R; Gelfer Y; Hartmann MD; Miotla P; Tamaian R; Govender P; Gurney-Champion OJ; Kauppila JH; Zhang X; Echeverría N; Subhash S; Sallmon H; Tofani M; Bae T; Bosch O; Cuív PO; Danchin A; Diouf B; Eerola T; Evangelou E; Filipp F; Klump H; Kurgan L; Smith SS; Terrier O; Tuttle N; Kohonen-Corish M; Lovell N; Webster R; Nakagawa-Lagisz M; Tahir N; Rouet R; Sharma S; Seib KL; Litfin T, 2019, 'Large expert-curated database for benchmarking document similarity detection in biomedical literature search', Database, 2019, pp. 1 - 67, http://dx.doi.org/10.1093/database/baz085
2019
Semchenko EA; Tan A; Borrow R; Seib KL, 2019, 'The Serogroup B Meningococcal Vaccine Bexsero Elicits Antibodies to Neisseria gonorrhoeae', Clinical Infectious Diseases, 69, pp. 1101 - 1111, http://dx.doi.org/10.1093/cid/ciy1061
2019
Atack JM; Murphy TF; Pettigrew MM; Seib KL; Jennings MP, 2019, 'Non-typeable Haemophilus influenzae isolates from patients with chronic obstructive pulmonary disease contain new phase-variable modA methyltransferase alleles controlling phasevarions', Scientific Reports, 9, http://dx.doi.org/10.1038/s41598-019-52429-6
2019
Jen FEC; Seib KL; Tan A, 2019, 'Screening DNA repeat tracts of phase variable genes by fragment analysis', , 1969, pp. 93 - 104, http://dx.doi.org/10.1007/978-1-4939-9202-7_6
2019
Seib KL; Haag AF; Oriente F; Fantappiè L; Borghi S; Semchenko EA; Schulz BL; Ferlicca F; Taddei AR; Giuliani MM; Pizza M; Delany I, 2019, 'The meningococcal vaccine antigen GNA2091 is an analogue of YraP and plays key roles in outer membrane stability and virulence', FASEB Journal, 33, pp. 12324 - 12335, http://dx.doi.org/10.1096/fj.201900669R
2019
Blakeway LV; Tan A; Jurcisek JA; Bakaletz LO; Atack JM; Peak IR; Seib KL, 2019, 'The Moraxella catarrhalis phase-variable DNA methyltransferase ModM3 is an epigenetic regulator that affects bacterial survival in an in vivo model of otitis media', BMC Microbiology, 19, http://dx.doi.org/10.1186/s12866-019-1660-y
2019
Hare KM; Seib KL; Chang AB; Harris TM; Spargo JC; Smith-Vaughan HC, 2019, 'Antimicrobial susceptibility and impact of macrolide antibiotics on moraxella catarrhalis in the upper and lower airways of children with chronic endobronchial suppuration', Journal of Medical Microbiology, 68, pp. 1140 - 1147, http://dx.doi.org/10.1099/jmm.0.001033
2019
Phillips ZN; Husna AU; Jennings MP; Seib KL; Atack JM, 2019, 'Phasevarions of bacterial pathogens-phase-variable epigenetic regulators evolving from restriction-modification systems', Microbiology United Kingdom, 165, pp. 917 - 928, http://dx.doi.org/10.1099/mic.0.000805
2019
Jen FEC; Semchenko EA; Day CJ; Seib KL; Jennings MP, 2019, 'The Neisseria gonorrhoeae methionine sulfoxide reductase (MsrA/B) is a surface exposed, immunogenic, vaccine candidate', Frontiers in Immunology, 10, http://dx.doi.org/10.3389/fimmu.2019.00137
2019
Day CJ; Hartley-Tassell LE; Seib KL; Tiralongo J; Bovin N; Savino S; Masignani V; Jennings MP, 2019, 'Lectin activity of Pseudomonas aeruginosa vaccine candidates PSE17-1, PSE41-5 and PSE54', Biochemical and Biophysical Research Communications, 513, pp. 287 - 290, http://dx.doi.org/10.1016/j.bbrc.2019.03.092
2019
Semchenko EA; Everest-Dass AV; Jen FEC; Mubaiwa TD; Day CJ; Seib KL, 2019, 'Glycointeractome of neisseria gonorrhoeae: Identification of host glycans targeted by the gonococcus to facilitate adherence to cervical and urethral epithelial cells', Mbio, 10, http://dx.doi.org/10.1128/mBio.01339-19
2019
Atack JM; Murphy TF; Pettigrew MM; Seib KL; Jennings MP, 2019, 'Transcriptome sequencing data sets for determining gene expression changes mediated by phase-variable DNA methyltransferases in nontypeable haemophilus influenzae strains isolated from patients with chronic obstructive pulmonary disease', Microbiology Resource Announcements, 8, http://dx.doi.org/10.1128/MRA.00526-19
2019
Phillips ZN; Tram G; Seib KL; Atack JM, 2019, 'Phase-variable bacterial loci: How bacteria gamble to maximise fitness in changing environments', Biochemical Society Transactions, 47, pp. 1131 - 1141, http://dx.doi.org/10.1042/BST20180633
2019
Tan A; Li WS; Verderosa AD; Blakeway LV; D. Mubaiwa T; Totsika M; Seib KL, 2019, 'Moraxella catarrhalis NucM is an entry nuclease involved in extracellular DNA and RNA degradation, cell competence and biofilm scaffolding', Scientific Reports, 9, http://dx.doi.org/10.1038/s41598-019-39374-0
2019
Jayasundara P; Regan DG; Seib KL; Jayasundara D; Wood JG, 2019, 'Modelling the in-host dynamics of Neisseria gonorrhoeae infection', Pathogens and Disease, 77, http://dx.doi.org/10.1093/femspd/ftz008
2019
Seib KL; Peak IR, 2019, 'Preface', Methods in Molecular Biology, 1969, pp. v - vii
2019
Atack JM; Yang Y; Seib KL; Zhou Y; Jennings MP, 2018, 'A survey of Type III restriction-modification systems reveals numerous, novel epigenetic regulators controlling phase-variable regulons; phasevarions', Nucleic Acids Research, 46, pp. 3532 - 3542, http://dx.doi.org/10.1093/NAR/GKY192
2018
Atack JM; Tan A; Bakaletz LO; Jennings MP; Seib KL, 2018, 'Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies', Trends in Microbiology, 26, pp. 715 - 726, http://dx.doi.org/10.1016/j.tim.2018.01.008
2018
Mubaiwa TD; Hartley-Tassell LE; Semchenko EA; Day CJ; Jennings MP; Seib KL, 2018, 'The Bexsero Neisseria meningitidis serogroup B vaccine antigen NHBA is a high-affinity chondroitin sulfate binding protein', Scientific Reports, 8, http://dx.doi.org/10.1038/s41598-018-24639-x
2018
Seib K, 2018, 'Report from ASM 2018', MICROBIOLOGY AUSTRALIA, 39, pp. 173 - 175, http://dx.doi.org/10.1071/MA18051
2018
Edwards JL; Jennings MP; Seib KL, 2018, 'Neisseria gonorrhoeae vaccine development: Hope on the horizon?', Current Opinion in Infectious Diseases, 31, pp. 246 - 250, http://dx.doi.org/10.1097/QCO.0000000000000450
2018
Seib KL; Jennings MP; Day CJ, 2018, 'Characterizing the meningococcal glycointeractome: What is new?', Future Microbiology, 13, pp. 279 - 282, http://dx.doi.org/10.2217/fmb-2017-0222
2018
Atack JM; Murphy TF; Bakaletz LO; Seib KL; Jennings MP, 2018, 'Closed complete genome sequences of two nontypeable haemophilus influenzae strains containing novel modA alleles from the sputum of patients with chronic obstructive pulmonary disease', Microbiology Resource Announcements, 7, http://dx.doi.org/10.1128/MRA.00821-18
2018
Blakeway LV; Tan A; Lappan R; Ariff A; Pickering JL; Peacock CS; Blyth CC; Kahler CM; Chang BJ; Lehmann D; Kirkham LAS; Murphy TF; Jennings MP; Bakaletz LO; Atack JM; Peak IR; Seib KL, 2018, 'Moraxella catarrhalis Restriction–Modification Systems Are Associated with Phylogenetic Lineage and Disease', Genome Biology and Evolution, 10, pp. 2932 - 2946, http://dx.doi.org/10.1093/gbe/evy226
2018
Semchenko EA; Day CJ; Seib KL, 2017, 'MetQ of Neisseria gonorrhoeae is a surfaceexpressed antigen that elicits bactericidal and functional blocking antibodies', Infection and Immunity, 85, http://dx.doi.org/10.1128/IAI.00898-16
2017
Seib KL; Jen FEC; Scott AL; Tan A; Jennings MP, 2017, 'Phase variation of DNA methyltransferases and the regulation of virulence and immune evasion in the pathogenic Neisseria', Pathogens and Disease, 75, http://dx.doi.org/10.1093/femspd/ftx080
2017
Blakeway LV; Tan A; Peak IRA; Seib KL, 2017, 'Virulence determinants of moraxella catarrhalis: Distribution and considerations for vaccine development', Microbiology United Kingdom, 163, pp. 1371 - 1384, http://dx.doi.org/10.1099/mic.0.000523
2017
Mubaiwa TD; Semchenko EA; Hartley-Tassell LE; Day CJ; Jennings MP; Seib KL, 2017, 'The sweet side of the pathogenic Neisseria: The role of glycan interactions in colonisation and disease', Pathogens and Disease, 75, http://dx.doi.org/10.1093/femspd/ftx063
2017
Day CJ; Paton AW; Harvey RM; Hartley-Tassell LE; Seib KL; Tiralongo J; Bovin N; Savino S; Masignani V; Paton JC; Jennings MP, 2017, 'Lectin activity of the pneumococcal pilin proteins', Scientific Reports, 7, http://dx.doi.org/10.1038/s41598-017-17850-9
2017
Mubaiwa TD; Hartley-Tassell LE; Semchenko EA; Jen FEC; Srikhanta YN; Day CJ; Jennings MP; Seib KL, 2017, 'The glycointeractome of serogroup B Neisseria meningitidis strain MC58', Scientific Reports, 7, http://dx.doi.org/10.1038/s41598-017-05894-w
2017
Tan A; Blakeway LV; Bakaletz LO; Boitano M; Clark TA; Korlach J; Jennings MP; Peak IR; Seib KL, 2017, 'Complete genome sequence of Moraxella catarrhalis strain CCRI- 195ME, isolated from the middle ear', Genome Announcements, 5, http://dx.doi.org/10.1128/genomeA.00384-17
2017
Seib KL, 2017, 'Gonorrhoea vaccines: a step in the right direction', Lancet, 390, pp. 1567 - 1569, http://dx.doi.org/10.1016/S0140-6736(17)31605-7
2017
Semchenko EA; Seib KL, 2016, 'Intractable problems require novel solutions: It's time to get serious about developing a gonorrhoea vaccine', Sexually Transmitted Infections, 92, pp. 561 - 562, http://dx.doi.org/10.1136/sextrans-2015-052378
2016
Tan A; Hill DMC; Harrison OB; Srikhanta YN; Jennings MP; Maiden MCJ; Seib KL, 2016, 'Distribution of the type III DNA methyltransferases modA, modB and modD among Neisseria meningitidis genotypes: Implications for gene regulation and virulence', Scientific Reports, 6, http://dx.doi.org/10.1038/srep21015
2016
Vacca I; Del Tordello E; Gasperini G; Pezzicoli A; Di Fede M; Paccani SR; Marchi S; Mubaiwa TD; Hartley-Tassell LE; Jennings MP; Seib KL; Masignani V; Pizza M; Serruto D; Aricò B; Delany I, 2016, 'Neisserial heparin binding antigen (NHBA) contributes to the adhesion of Neisseria meningitidis to human epithelial cells', Plos One, 11, http://dx.doi.org/10.1371/journal.pone.0162878
2016
Tan A; Atack JM; Jennings MP; Seib KL, 2016, 'The capricious nature of bacterial pathogens: Phasevarions and vaccine development', Frontiers in Immunology, 7, http://dx.doi.org/10.3389/fimmu.2016.00586
2016
Edwards JL; Jennings MP; Apicella MA; Seib KL, 2016, 'Is gonococcal disease preventable? The importance of understanding immunity and pathogenesis in vaccine development', Critical Reviews in Microbiology, 42, pp. 928 - 941, http://dx.doi.org/10.3109/1040841X.2015.1105782
2016
Seib KL; Jen FEC; Tan A; Scott AL; Kumar R; Power PM; Chen LT; Wu HJ; Wang AHJ; Hill DMC; Luyten YA; Morgan RD; Roberts RJ; Maiden MCJ; Boitano M; Clark TA; Korlach J; Rao DN; Jennings MP, 2015, 'Specificity of the ModA11, ModA12 and ModD1 epigenetic regulator N6-adenine DNA methyltransferases of Neisseria meningitidis', Nucleic Acids Research, 43, pp. 4150 - 4162, http://dx.doi.org/10.1093/nar/gkv219
2015
Newton HJ; Seib KL, 2015, 'Science meets Parliament 2015', MICROBIOLOGY AUSTRALIA, 36, pp. 140 - +, http://dx.doi.org/10.1071/MA15048
2015
Seib KL; Scarselli M; Comanducci M; Toneatto D; Masignani V, 2015, 'Neisseria meningitidis factor H-binding protein fHbp: Key virulence factor and vaccine antigen', Expert Review of Vaccines, 14, pp. 841 - 859, http://dx.doi.org/10.1586/14760584.2015.1016915
2015
Craig AP; Gray RT; Edwards JL; Apicella MA; Jennings MP; Wilson DP; Seib KL, 2015, 'The potential impact of vaccination on the prevalence of gonorrhea', Vaccine, 33, pp. 4520 - 4525, http://dx.doi.org/10.1016/j.vaccine.2015.07.015
2015
Jen FEC; Seib KL; Jennings MP, 2014, 'Phasevarions mediate epigenetic regulation of antimicrobial susceptibility in Neisseria meningitidis', Antimicrobial Agents and Chemotherapy, 58, pp. 4219 - 4221, http://dx.doi.org/10.1128/AAC.00004-14
2014
Blakeway LV; Power PM; Jen FEC; Worboys SR; Boitano M; Clark TA; Korlach J; Bakaletz LO; Jennings MP; Peak IR; Seib KL, 2014, 'ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media', FASEB Journal, 28, pp. 5197 - 5207, http://dx.doi.org/10.1096/fj.14-256578
2014
Nesta B; Valeri M; Spagnuolo A; Rosini R; Mora M; Donato P; Alteri CJ; Del Vecchio M; Buccato S; Pezzicoli A; Bertoldi I; Buzzigoli L; Tuscano G; Falduto M; Rippa V; Ashhab Y; Bensi G; Fontana MR; Seib KL; Mobley HLT; Pizza M; Soriani M; Serino L, 2014, 'SslE Elicits Functional Antibodies That Impair In Vitro Mucinase Activity and In Vivo Colonization by Both Intestinal and Extraintestinal Escherichia coli Strains', Plos Pathogens, 10, http://dx.doi.org/10.1371/journal.ppat.1004124
2014
Delany I; Rappuoli R; Seib KL, 2013, 'Vaccines, reverse vaccinology, and bacterial pathogenesis', Cold Spring Harbor Perspectives in Medicine, 3, http://dx.doi.org/10.1101/cshperspect.a012476
2013
Seib KL; Zhao X; Rappuoli R, 2012, 'Developing vaccines in the era of genomics: A decade of reverse vaccinology', Clinical Microbiology and Infection, 18, pp. 109 - 116, http://dx.doi.org/10.1111/j.1469-0691.2012.03939.x
2012
Moriel DG; Rosini R; Seib KL; Serino L; Pizza M; Rappuoli R, 2012, 'Escherichia coli: Great diversity around a common core', Mbio, 3, http://dx.doi.org/10.1128/mBio.00118-12
2012
Veggi D; Gentile MA; Cantini F; Lo Surdo P; Nardi-Dei V; Seib KL; Pizza M; Rappuoli R; Banci L; Savino S; Scarselli M, 2012, 'The factor h binding protein of neisseria meningitidis interacts with xenosiderophores in vitro', Biochemistry, 51, pp. 9384 - 9393, http://dx.doi.org/10.1021/bi301161w
2012
Seib KL; Pigozzi E; Muzzi A; Gawthorne JA; Delany I; Jennings MP; Rappuoli R, 2011, 'A novel epigenetic regulator associated with the hypervirulent Neisseria meningitidis clonal complex 41/44', FASEB Journal, 25, pp. 3622 - 3633, http://dx.doi.org/10.1096/fj.11-183590
2011
Seib KL; Brunelli B; Brogioni B; Palumbo E; Bambini S; Muzzi A; DiMarcello F; Marchi S; Van Der Ende A; Aricó B; Savino S; Scarselli M; Comanducci M; Rappuoli R; Giuliani MM; Pizza M, 2011, 'Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce bactericidal antibodies', Infection and Immunity, 79, pp. 970 - 981, http://dx.doi.org/10.1128/IAI.00891-10
2011
Budroni S; Siena E; Dunning Hotopp JC; Seib KL; Serruto D; Nofroni C; Comanducci M; Riley DR; Daugherty SC; Angiuoli SV; Covacci A; Pizza M; Rappuoli R; Moxon ER; Tettelin H; Medini D, 2011, 'Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination', Proceedings of the National Academy of Sciences of the United States of America, 108, pp. 4494 - 4499, http://dx.doi.org/10.1073/pnas.1019751108
2011
Echenique-Rivera H; Muzzi A; Del Tordello E; Seib KL; Francois P; Rappuoli R; Pizza M; Serruto D, 2011, 'Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival', Plos Pathogens, 7, http://dx.doi.org/10.1371/journal.ppat.1002027
2011
Seib KL; Oriente F; Adu-Bobie J; Montanari P; Ferlicca F; Giuliani MM; Rappuoli R; Pizza M; Delany I, 2010, 'Influence of serogroup B meningococcal vaccine antigens on growth and survival of the meningococcus in vitro and in ex vivo and in vivo models of infection', Vaccine, 28, pp. 2416 - 2427, http://dx.doi.org/10.1016/j.vaccine.2009.12.082
2010
Serruto D; Spadafina T; Ciucchi L; Lewis LA; Ram S; Tontini M; Santini L; Biolchi A; Seib KL; Giuliani MM; Donnelly JJ; Berti F; Savino S; Scarselli M; Costantino P; Simon Kroll J; O'Dwyer C; Qiu J; Plaut AG; Moxon R; Rappuoli R; Pizza M; Aricò B, 2010, 'Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans', Proceedings of the National Academy of Sciences of the United States of America, 107, pp. 3770 - 3775, http://dx.doi.org/10.1073/pnas.0915162107
2010
Wu HJ; Seib KL; Srikhanta YN; Edwards J; Kidd SP; Maguire TL; Hamilton A; Pan KT; Hsiao HH; Yao CW; Grimmond SM; Apicella MA; McEwan AG; Wang AHJ; Jennings MP, 2010, 'Manganese regulation of virulence factors and oxidative stress resistance in Neisseria gonorrhoeae', Journal of Proteomics, 73, pp. 899 - 916, http://dx.doi.org/10.1016/j.jprot.2009.12.001
2010
Seib KL; Serruto D; Oriente F; Delany I; Adu-Bobie J; Veggi D; Aricò B; Rappuoli R; Pizza M, 2009, 'Factor H-binding protein is important for meningococcal survival in human whole blood and serum and in the presence of the antimicrobial peptide LL-37', Infection and Immunity, 77, pp. 292 - 299, http://dx.doi.org/10.1128/IAI.01071-08
2009
Fantappiè L; Metruccio MME; Seib KL; Oriente F; Cartocci E; Ferlicca F; Giuliani MM; Scarlato V; Delany I, 2009, 'The RNA chaperone Hfq is involved in stress response and virulence in Neisseria meningitidis and is a pleiotropic regulator of protein expression', Infection and Immunity, 77, pp. 1842 - 1853, http://dx.doi.org/10.1128/IAI.01216-08
2009
Rinaudo CD; Telford JL; Rappuoli R; Seib KL, 2009, 'Vaccinology in the genome era', Journal of Clinical Investigation, 119, pp. 2515 - 2525, http://dx.doi.org/10.1172/JCI38330
2009
Seib KL; Dougan G; Rappuoli R, 2009, 'The key role of genomics in modern vaccine and drug design for emerging infectious diseases', Plos Genetics, 5, http://dx.doi.org/10.1371/journal.pgen.1000612
2009
Srikhanta YN; Dowideit SJ; Edwards JL; Falsetta ML; Wu HJ; Harrison OB; Fox KL; Seib KL; Maguire TL; Wang AHJ; Maiden MC; Grimmond SM; Apicella MA; Jennings MP, 2009, 'Phasevarions mediate random switching of gene expression in pathogenic Neisseria', Plos Pathogens, 5, http://dx.doi.org/10.1371/journal.ppat.1000400
2009
Ieva R; Roncarati D; Metruccio MME; Seib KL; Scarlato V; Delany I, 2008, 'OxyR tightly regulates catalase expression in Neisseria meningitidis through both repression and activation mechanisms', Molecular Microbiology, 70, pp. 1152 - 1165, http://dx.doi.org/10.1111/j.1365-2958.2008.06468.x
2008
Seib KL; Wu HJ; Srikhanta YN; Edwards JL; Falsetta ML; Hamilton AJ; Maguire TL; Grimmond SM; Apicella MA; McEwan AG; Jennings MP, 2007, 'Characterization of the OxyR regulon of Neisseria gonorrhoeae', Molecular Microbiology, 63, pp. 54 - 68, http://dx.doi.org/10.1111/j.1365-2958.2006.05478.x
2007
Power PM; Seib KL; Jennings MP, 2006, 'Pilin glycosylation in Neisseria meningitidis occurs by a similar pathway to wzy-dependent O-antigen biosynthesis in Escherichia coli', Biochemical and Biophysical Research Communications, 347, pp. 904 - 908, http://dx.doi.org/10.1016/j.bbrc.2006.06.182
2006
Wu HJ; Seib KL; Srikhanta YN; Kidd SP; Edwards JL; Maguire TL; Grimmond SM; Apicella MA; McEwan AG; Jennings MP, 2006, 'PerR controls Mn-dependent resistance to oxidative stress in Neisseria gonorrhoeae', Molecular Microbiology, 60, pp. 401 - 416, http://dx.doi.org/10.1111/j.1365-2958.2006.05079.x
2006
Seib KL; Wu HJ; Kidd SP; Apicella MA; Jennings MP; McEwan AG, 2006, 'Defenses against oxidative stress in Neisseria gonorrhoeae: A system tailored for a challenging environment', Microbiology and Molecular Biology Reviews, 70, pp. 344 - 361, http://dx.doi.org/10.1128/MMBR.00044-05
2006
Seib KL; Simons MP; Wu HJ; McEwan AG; Nauseef WM; Apicella MA; Jennings MP, 2005, 'Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay', Infection and Immunity, 73, pp. 5269 - 5272, http://dx.doi.org/10.1128/IAI.73.8.5269-5272.2005
2005
Wu HJ; Seib KL; Edwards JL; Apicella MA; McEwan AG; Jennings MP, 2005, 'Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells', Infection and Immunity, 73, pp. 8444 - 8448, http://dx.doi.org/10.1128/IAI.73.12.8444-8448.2005
2005
Seib KL; Tseng HJ; McEwan AG; Apicella MA; Jennings MP, 2004, 'Defenses against oxidative stress in Neisseria gonorrhoeae and Neisseria meningitidis: Distinctive systems for different lifestyles', Journal of Infectious Diseases, 190, pp. 136 - 147, http://dx.doi.org/10.1086/421299
2004
Seib KL; Jennings MP; McEwan AG, 2003, 'A Sco homologue plays a role in defence against oxidative stress in pathogenic Neisseria', FEBS Letters, 546, pp. 411 - 415, http://dx.doi.org/10.1016/S0014-5793(03)00632-X
2003
Seib KL; Peak IRA; Jennings MP, 2002, 'Phase variable restriction-modification systems in Moraxella catarrhalis', FEMS Immunology and Medical Microbiology, 34, pp. 159 - 165, http://dx.doi.org/10.1111/j.1574-695X.2002.tb00548.x
2002
Seib KL; Peak IRA; Jennings MP, 2002, 'Phase variable restriction-modification systems in Moraxella catarrhalis', FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 32, pp. 159 - 165
2002
Semchenko EA; Jen FEC; Jennings MP; Seib KL, 2022, 'Assessment of Serum Bactericidal and Opsonophagocytic Activity of Antibodies to Gonococcal Vaccine Targets', in Methods in Molecular Biology, pp. 363 - 372, http://dx.doi.org/10.1007/978-1-0716-1900-1_19
2022
Seib KL; Jennings MP, 2021, 'Epigenetics of infectious diseases', in Medical Epigenetics, pp. 407 - 424, http://dx.doi.org/10.1016/B978-0-12-823928-5.00016-5
2021
Seib KL; Srikhanta YN; Atack JM; Jennings MP, 2020, 'Epigenetic Regulation of Virulence and Immunoevasion by Phase-Variable Restriction-Modification Systems in Bacterial Pathogens', in Gottesman S (ed.), ANNUAL REVIEW OF MICROBIOLOGY, VOL 74, 2020, ANNUAL REVIEWS, pp. 655 - 671, http://dx.doi.org/10.1146/annurev-micro-090817-062346
2020
Mubaiwa TD; Hartley-Tassell LE; Semchenko EA; Day CJ; Jennings MP; Seib KL, 2019, 'Investigation of whole cell meningococcal glycan interactions using high throughput glycobiology techniques: Glycan array and surface plasmon resonance', in Methods in Molecular Biology, pp. 113 - 121, http://dx.doi.org/10.1007/978-1-4939-9202-7_8
2019
Seib KL; Jennings MP, 2016, 'Epigenetics of Infectious Diseases', in Medical Epigenetics, pp. 443 - 458, http://dx.doi.org/10.1016/B978-0-12-803239-8.00024-7
2016
Serino L; Seib KL; Pizza M, 2012, 'Design of new vaccines in the genomic and post-genomic era', in Innovation in Vaccinology from Design Through to Delivery and Testing, pp. 3 - 15, http://dx.doi.org/10.1007/978-94-007-4543-8_1
2012
Seib KL; Semchenko E; Eskandari S; Taha ; Slesarenko V; Huges I; O'Sullivan M; Thing C, 2022, 'Characterization of Meningococcal Vaccine--Induced Antibodies to Neisseria gonorrhoeae', in SEXUALLY TRANSMITTED DISEASES, LIPPINCOTT WILLIAMS & WILKINS, MA, Boston, pp. S52 - S53, presented at Annual Meeting of the Infectious-Diseases-Society-for-Obstetrics-and-Gynecology (IDSOG), MA, Boston, 04 August 2022 - 06 August 2022
2022
Seib KL, 2019, 'PROGRESS TOWARDS A GONORRHOEA VACCINE', in SEXUALLY TRANSMITTED INFECTIONS, BMJ PUBLISHING GROUP, pp. A20 - A20, http://dx.doi.org/10.1136/sextrans-2019-sti.57
2019
Seib KL; Semchenko EA, 2017, 'VACCINE DEVELOPMENT TO COMBAT ANTIMICROBIAL RESISTANT GONORRHOEA', in SEXUALLY TRANSMITTED INFECTIONS, BMJ PUBLISHING GROUP, pp. A30 - A30, http://dx.doi.org/10.1136/sextrans-2017-053264.74
2017
, 2019, Neisseria meningitidis, Seib KL; Peak IR, (ed.), Springer New York, http://dx.doi.org/10.1007/978-1-4939-9202-7
2019

Prof Seib currently holds an NHMRC Investigator grant (leadership level 2).  She has been a CI on several grants from the NHMRC (CJ Martin Fellowship, Career Development Award, Project, Ideas, Clinical Trials and Cohorts, Centre for Research Excellence), ARC (Discovery), NIH (U19, R01), the vaccine industry, and philanthropic organisations.

Key highlights include:

Meningococcal vaccine development.
While at Novartis Vaccines in Italy (now GSK), Prof Seib was involved in the development of the serogroup B Neisseria meningitidis vaccine, 4CMenB (Bexsero). She played a key role in the characterization of the vaccine antigens, in terms of their functional roles and their ability to induce an immune response. 4CMenB has been approved in approximately 40 countries and more than 50 million doses have been distributed since 2013, resulting in a substantial reduction in meningococcal disease. 

Prof Seib recently investigated 4CMenB immune responses as part of a multidisciplinary team that showed giving antibiotics to newborns can reduce their immune response to vaccines.

Ryan FJ, Clarke M, Lynn MA, Benson SC, McAlister S, Giles LC, Choo JM, Rossouw C, Ng YY, Semchenko EA, Richard A, Leong LEX, Taylor SL, Blake SJ, Mugabushaka JI, Walker M, Wesselingh SL, Licciardi PV, SEIB KL, Tumes DJ, Richmond P, Rogers GB, Marshall HS, Lynn DJ. (2025). Bifidobacteria support optimal infant vaccine responses. Nature, 641(8062):456-464.

Meningococcal vaccine cross protection against gonorrhea. 
Several observational studies have indicated that 4CMenB may provide cross protection against the closely related Neisseria gonorrhoeae, and the UK has recently rolled out the 4CMenB for gonorrhea prevention in groups at high risk of infection.
Prof Seib led the team that demonstrated that 4CMenB induces antibodies that cross-react with gonorrhea.

Semchenko EA, Tan A, Borrow R, SEIB KL. (2019) The serogroup B meningococcal vaccine Bexsero elicits antibodies to Neisseria gonorrhoeae. Clinical Infectious Diseases, 69: 1101-1111.

She has led two clinical trials to test the effectiveness of 4CMenB against gonorrhea in men who have sex with men. The GoGoVax Trial co-led by Prof Andrew Grulich and Prof Basil Donovan (ClinicalTrials.gov:NCT04415424) was run at 7 sites with a team of >26 clinicians and researchers, funded by an Australian NHMRC. The MenGo Trial (ANZCTR:12619001478101) run at a single site, funded by the Gold Coast Hospital Foundation. 

Gonococcal vaccine development.
 Prof Seib co-discovered and characterised several potential gonococcal vaccine antigens (e.g., papers 4-6) that are under preclinical evaluation. She holds patents for these antigens that were included in a recent, multimillion dollar licence deal with LimmaTech Biologics.

She has also conducted mathematical modelling with A/Prof David Regan, Prof Richard Gray, Prof James Wood, and Dr Ben Hui to investigate potential vaccine characteristics and immunisation strategies needed for a gonococcal vaccine to be effective.

Hui, BB, Padeniya, TN, Rebuli, N, Gray, RT, Wood, JG, Donovan, B, Duan, Q, Guy, R, Hocking, JS, Lahra, MM, Lewis DA, Whiley DM, Regan DG, SEIB KL (2022) A Gonococcal Vaccine has the Potential to Rapidly Reduce the Incidence of Neisseria gonorrhoeae Infection Among Urban Men Who Have Sex With Men. Journal of Infectious Diseases. 225:983-993