The Clinical, Experimental and Computational Immunology Group applies frontier laboratory techniques in cellular and molecular biology to critical challenges in clinical medicine. As the name suggests, we are increasingly using bioinformatic approaches to large datasets including single-cell transcriptomics. Our current projects investigate respiratory sepsis caused by COVID-19 and other viral and bacterial pathogens. We are also studying the underlying mechanisms of severe acute pancreatitis. We are interested in the host immune response to virally driven cancers, particularly those caused by human papilloma virus. Our work aims to increase the understanding of disease processes, through the study of primary tissue samples, in order to identify targets for novel therapeutic strategies. We have active collaborations with colleagues in the Immunovirology and Pathogenesis Program as well as researchers in the Viral Immunology Systems Program, HIV Epidemiology and Prevention Program and Infection Analytics Program. We have active research programs with The George Institute, Garvan Institute and clinical departments in Immunology, Rheumatology, Infectious Diseases, Intensive Care, Haematology, Neurology and Gastroenterology across the Sydney basin.